I'm posting this in case it interests anyone. If nothing else, if you know someone who developed or develops any sort of endocrine disruption/disease post Covid OR VACCINE.
In general, it suggests NOT accepting the "standard" treatment of iodine irradiation/ throid killing if you happen to be diagnosed with Graves down the road.
I did this sleuthing for a friend. I was actually surprised I found so many useful articles/research.
excerpt and links:
Our prior discussion and your concerns led me to do a *little* sleuthing for Covid-19+endocrine and, then, "spike proteins and graves disease". I was actually surprised at the number of useful hits, since the link is not talked about and probably the risk is not considered whatsoever!
Getting off gluten is the first thing the M.D. cited below recommends at this point. Then dealing with "leaky gut".
A SEPARATE search found a relationship between Covid->endocrine->Graves->adrenal insufficiency (which is what I suspected might be an issue with thyroid). Was X tested for adrenal insufficiency and is she currently being tested? (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601687/. "COVID-19 targets human adrenal glands")
Covid-19 DOES contribute to autoimmune diseases in general, endocrine system disruption, and has even been (pretty heavily, imo) implicated with triggering Graves disease:
https://pubmed.ncbi.nlm.nih.gov/34939881/.
Graves Disease Following the SARS-CoV-2 Vaccine: Case Series
Michael A Weintraub 1 , Barbara Ameer 2 , Naina Sinha Gregory 1
Affiliations
PMID: 34939881
PMCID: PMC8724979
DOI: 10.1177/23247096211063356
Free PMC article
Abstract
Widespread vaccination is a principal strategy to mitigate the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and lessen the global burden of coronavirus disease 2019 (COVID-19). Information is rapidly evolving about the impact of SARS-CoV-2 vaccines on the immune and endocrine systems. This case series heightens clinical awareness of possible thyroid effects and conveys knowledge of what to monitor, which are fundamental components of public health and pharmacovigilance. We present a case series of Graves disease following mRNA SARS-CoV-2 vaccination, with symptoms and altered thyroid function tests developing within 7 days of the first dose in 2 women aged 38 and 63 years, and 28 days after the second dose in a 30-year-old man. New-onset Graves disease occurred following administration of mRNA vaccines against SARS-CoV-2. Based on the timing of signs and symptoms relative to administration of the vaccine and the absence of other probable causes, we consider the vaccine as a potential contributor to the diagnosis. The viral spike protein, delivered indirectly through an encoded mRNA vaccine, may be capable of triggering an inflammatory cascade and immune response triggering thyroid dysfunction.
Keywords: COVID-19 vaccines; Graves disease; SARS-CoV-2; case report; endocrinology; immunology; pharmacovigilance.
Conflict of interest statement
Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Figures
Figure 1.
Figure 1.
Timeline depicts onset of symptoms…
Similar articles
Development of Graves' Disease After SARS-CoV-2 mRNA Vaccination: A Case Report and Literature Review.
Lui DTW, Lee KK, Lee CH, Lee ACH, Hung IFN, Tan KCB. Front Public Health. 2021 Nov 23;9:778964. doi: 10.3389/fpubh.2021.778964. eCollection 2021. PMID: 34888290 Free PMC article. Review.
mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status.
Neidleman J, Luo X, McGregor M, Xie G, Murray V, Greene WC, Lee SA, Roan NR. Elife. 2021 Oct 12;10:e72619. doi: 10.7554/eLife.72619. PMID: 34636722 Free PMC article.
Graves' disease following administration of second dose of SARS-CoV-2 vaccine.
Goblirsch TJ, Paulson AE, Tashko G, Mekonnen AJ. BMJ Case Rep. 2021 Dec 30;14(12):e246432. doi: 10.1136/bcr-2021-246432. PMID: 34969799 Free PMC article.
SARS-CoV-2 mRNA Vaccination and Graves' Disease: A Report of 12 Cases and Review of the Literature.
Chee YJ, Liew H, Hoi WH, Lee Y, Lim B, Chin HX, Lai RTR, Koh Y, Tham M, Seow CJ, Quek ZH, Chen AW, Quek TPL, Tan AWK, Dalan R. J Clin Endocrinol Metab. 2022 May 17;107(6):e2324-e2330. doi: 10.1210/clinem/dgac119. PMID: 35235663 Free PMC article. Review.
High-Resolution Linear Epitope Mapping of the Receptor Binding Domain of SARS-CoV-2 Spike Protein in COVID-19 mRNA Vaccine Recipients.
Nitahara Y, Nakagama Y, Kaku N, Candray K, Michimuko Y, Tshibangu-Kabamba E, Kaneko A, Yamamoto H, Mizobata Y, Kakeya H, Yasugi M, Kido Y. Microbiol Spectr. 2021 Dec 22;9(3):e0096521. doi: 10.1128/Spectrum.00965-21. Epub 2021 Nov 10. PMID: 34756082 Free PMC article.
See all similar articles
Cited by
Ocular motility disorders following coronavirus disease-19 vaccination.
Park KA, Jeon H, Choi DG, Jung JH, Shin HJ, Lee BJ, Moon Y, Lee SY, Lee DC, Cho SY, Kim SJ, Oh SY, Moon S, Oh SY, Choi DD, Choi MY, Kim WJ, Kim US, Lee HJ, Kim Y. Graefes Arch Clin Exp Ophthalmol. 2022 Nov 16. doi: 10.1007/s00417-022-05888-z. Online ahead of print. PMID: 36383278
Graves' disease following vaccination against SARS-CoV-2: A systematic review of the reported cases.
Triantafyllidis KK, Giannos P, Stathi D, Kechagias KS. Front Endocrinol (Lausanne). 2022 Sep 27;13:938001. doi: 10.3389/fendo.2022.938001. eCollection 2022. PMID: 36237182 Free PMC article.
Graves' Disease Following SARS-CoV-2 Vaccination: A Systematic Review.
Patrizio A, Ferrari SM, Elia G, Ragusa F, Paparo SR, Mazzi V, Antonelli A, Fallahi P. Vaccines (Basel). 2022 Sep 1;10(9):1445. doi: 10.3390/vaccines10091445. PMID: 36146523 Free PMC article. Review.
[Thyroid and SARS-CoV-2].
Zettinig G. J Klin Endokrinol Stoffwechs. 2022;15(3):100-104. doi: 10.1007/s41969-022-00173-0. Epub 2022 Sep 2. PMID: 36068883 Free PMC article. German.
Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review.
RodrÃguez Y, Rojas M, Beltrán S, Polo F, Camacho-DomÃnguez L, Morales SD, Gershwin ME, Anaya JM. J Autoimmun. 2022 Aug 24;132:102898. doi: 10.1016/j.jaut.2022.102898. Online ahead of print. PMID: 36041291 Free PMC article. Review.
See all "Cited by" articles
References
Murugan AK, Alzahrani AS. SARS-CoV-2 plays a pivotal role in inducing hyperthyroidism of Graves’ disease. Endocrine. 2021;73:243-254. doi:10.1007/s12020-021-02770-6. - DOI - PMC - PubMed
Vera-Lastra O, Ordinola Navarro A, Cruz Domiguez MP, Medina G, Sánchez Valadez TI, Jara LJ. Two cases of Graves’ disease following SARS-CoV-2 vaccination: an autoimmune/inflammatory syndrome induced by adjuvants. Thyroid. 2021; 31:1436-1439. doi:10.1089/thy.2021.0142. - DOI - PubMed
Zettinig G, Krebs M. Two further cases of Graves’ disease following SARS-Cov-2 vaccination. J Endocrinol Invest. 2021. doi:10.1007/s40618-021-01650-0. - DOI - PMC - PubMed
Sriphrapradang C. Aggravation of hyperthyroidism after heterologous prime-boost immunization with inactivated and adenovirus-vectored SARS-CoV-2 vaccine in a patient with Graves’ disease. Endocrine. 2021;74:226-227. doi:10.1007/s12020-021-02879-8. - DOI - PMC - PubMed
Mateu-Salat M, Urgell E, Chico A. SARS-COV-2 as a trigger for autoimmune disease: report of two cases of Graves’ disease after COVID-19. J Endocrinol Invest. 2020;43:1527-1528. doi:10.1007/s40618-020-01366-7. - DOI - PMC - PubMed
------
Also found website of an M.D. who was diagnosed with Graves disease during her medical training and, it appears, has developed a functional (nutriional) approach to dealing with Graves AND AFTERMATH OF GETTING THE RADIOACTIVE IODINE TREATMENT (which she regrets she accepted; says surgical is a BETTER last ditch intervention as it leaves you some thyroid function).
https://www.amymyersmd.com/article/graves-disease-causes-solutions/