TL;DR? "A comparable dose for humans would be three to six grams a day.".
http://science.slashdot.org/story/23/06/08/2222201/common-energy-drink-ingredient-taurine-may-slow-aging-process
Common Energy Drink Ingredient Taurine 'May Slow Aging Process' 58
Posted by BeauHD on Thursday June 08, 2023 @09:00PM from the human-intervention-study-required dept.
Scientists are calling for a major clinical trial to investigate the potential benefits of taurine supplementation, a substance commonly found in energy drinks. Animal studies have shown that replenishing taurine levels to more youthful levels can slow down the aging process, improve health, and even extend lifespans in mice. The Guardian reports:
Prof Henning Wackerhage, a molecular exercise physiologist on the team at the Technical University of Munich, said a trial would compare how humans fared after taking daily taurine or placebo supplements. "It will probably be very difficult to look at whether they live longer, but at least we can check if they live healthier for longer, and that of course is the goal for medicine."
Yadav's team homed in on taurine as a potential driver of the ageing process in 2012 when an analysis of blood compounds found that levels of the amino acid dropped dramatically with age in mice, monkeys and humans. By the age of 60, taurine levels in a typical person slumped to one-third of that seen in five-year-olds, they found. The discovery prompted the team to test the impact of extra taurine on middle-aged mice. "Whatever we checked, taurine-supplemented mice were healthier and appeared younger than the control mice," Yadav said, noting they had denser bones, stronger muscles, better memory and younger looking immune systems. "Taurine made animals live healthier and longer lives by affecting all the major hallmarks of ageing." Beyond improving health, mice on taurine lived longer -- on average an extra 10% for males and 12% for females, amounting to an additional three to four months, the equivalent of seven or eight human years. A comparable dose for humans would be three to six grams a day.
The scientists next looked at whether boosting taurine benefited animals that were much closer biologically to humans. A six-month trial in middle-aged macaques found that a daily taurine pill appeared to boost health by preventing weight gain, lowering blood glucose and improving bone density and the immune system. Other evidence suggests taurine supplementation may have some effect in humans. Yadav and his team analysed medical data from 12,000 Europeans aged 60 and over. Those with higher taurine levels had less obesity, type 2 diabetes and high blood pressure, and lower levels of inflammation. Strenuous sessions on an exercise bike were found to boost taurine levels, the researchers report in Science.
Without a major trial to demonstrate the safety or any benefits of taurine supplements, the scientists are not recommending people boost their intake through pills, energy drinks or dietary changes. Taurine is made naturally in the body and is found in meat and shellfish diets, but the healthiest diets are largely plant-based. Some energy drinks contain taurine, but the scientists warn they also contain other substances that may not be safe to consume at high levels.
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