 |
| Msg. #
| Subject
| Posted by
| Board
| Date
| |
|
|
| 50263 |
The Blind Watchmaker
I'm approaching the end of my book and thought I'd share one of its salient points. Believe it or not, this succinct understanding of the disease was not achieved until January 2000:
The vast catalog of cancer cell genotypes is a manifestation of six essential alterations in cell physiology that collectively dictate malignant growth.1. Self-sufficiency in growth signals: cancer cells acquire an autonomous drive to proliferate - pathological mitosis - by virtue of the activation of oncogenes such as ras or myc.
2. Insensitivity to growth-inhibitory (antigrowth) signals: cancer cells inactivate tumor suppressor genes, such as retinoblastoma (Rb), that normally inhibit growth
3. Evasion of programmed cell death (apoptosis): cancer cells suppress and inactivate genes and pathways that normally enable cells to die.
4. Limitless replicative potential: cancer cells activate specific gene pathways that render them immortal even after generations of growth.
5. Sustained angiogenesis: cancer cells acquire the capacity to draw out their own supply of blood and blood vessels - tumor angiogenesis.
6. Tissue invasion and metastasis: cancer cells acquire the capacity to migrate to other organs, invade other tissues, and colonize these organs, resulting in their spread throughout the body.
Gold is $1,581/oz today. When it hits $2,000, it will be up 26.5%. Let's see how long that takes. - De 3/11/2013 - ANSWER: 7 Years, 5 Months |
|
| 